Submit Manuscript  

Article Details


A Brief Introduction to Porphyrin Compounds used in Tumor Imaging and Therapies

[ Vol. 21 , Issue. 11 ]

Author(s):

Lili Pan, Yu Ma, Xiaoai Wu, Huawei Cai, Feng Qin, Haoxing Wu, Yun Chun Li and Zhiyun Jia*   Pages 1303 - 1313 ( 11 )

Abstract:


As a group of heterocyclic macrocycle organic natural compounds occurring universally in animal tissues and plants, porphyrins are composed of four modified pyrrole subunits. Porphyrin analogues/ derivatives possess multiple biochemical properties because of their unique structures and have been extensively investigated in cancer treatment. Studies have shown that porphyrins and their derivatives have the ability to locate tumor cells in a variety of human cancers, and these compounds not only exhibit potent therapeutic effects as photodynamic agents but also show promising properties in medicinal imaging, such as MRI, photoacoustic imaging, fluorescence imaging, and PET/SPECT imaging. This paper reviews the recent reports of porphyrin derivatives as therapeutic agents used in tumor therapies, such as sonodynamic therapy, photodynamic therapy and radiotherapy, as well as the imaging agents for multimodality tumor imaging. The limitations of porphyrin-based compounds in tumor treatments and future prospects are also summarized.

Keywords:

Porphyrin, photosensitizers, sonodynamic agents, MRI contrast agents, radiotracers, tumor imaging.

Affiliation:

Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, Thyroid and Parathyroid surgery center, West China hospital, Sichuan University, Chengdu 610041, Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, Andrology Laboratory, West China Hospital, Sichuan University, Chengdu 610041, Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041



Read Full-Text article