Z.-J. Huang, Y. Zeng, P. Lan, P.-H. Sun and W.-M. Chen Pages 1122 - 1129 ( 8 )
Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome. This paper is a systematic review of the structural modifications of berberine for different biological activities such as antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, anti-inflammatory and antimalaria. The current review would provide some useful information for further studies on structural modification of berberine for discovering new drug leads.
Berberine, structural modification, biological activities, isoquinoline alkaloid, Chinese herbs, Coptidis Rhizome, antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, antimalaria
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China.