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Advances in Structural Modifications and Biological Activities of Berberine: An Active Compound in Traditional Chinese Medicine

[ Vol. 11 , Issue. 13 ]

Author(s):

Z.-J. Huang, Y. Zeng, P. Lan, P.-H. Sun and W.-M. Chen   Pages 1122 - 1129 ( 8 )

Abstract:


Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome. This paper is a systematic review of the structural modifications of berberine for different biological activities such as antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, anti-inflammatory and antimalaria. The current review would provide some useful information for further studies on structural modification of berberine for discovering new drug leads.

Keywords:

Berberine, structural modification, biological activities, isoquinoline alkaloid, Chinese herbs, Coptidis Rhizome, antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, antimalaria

Affiliation:

Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China.



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