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Stem Cell-Mediated Delivery of Therapies in the Treatment of Glioma

[ Vol. 11 , Issue. 7 ]

Author(s):

G. Frosina   Pages 591 - 598 ( 8 )

Abstract:


High grade gliomas can be seldom controlled, due to the infiltrative nature of these tumors and the presence of cell populations resistant to radio- and chemotherapy. Current research aims to develop novel therapeutic approaches to track and eliminate the disseminated glioma-driving cells. Selected delivery of therapeutic agents taking advantage of the tropism of normal stem cells for glioma cells might be one.

Keywords:

Glioma, stem, gene therapy, cancer, resistance, High grade, ADSC, bone morphogenetic protein, cytosine deaminase, cyclophosphamide, connexin 43, EGF, ganciclovir, mesenchymal stem cell

Affiliation:

Istituto Nazionale Ricerca Cancro, Molecular Mutagenesis&DNA Repair Unit, Genova, Italy.



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