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Recent Advances in the Development of Small-molecule CCR5 Inhibitors for HIV

[ Vol. 10 , Issue. 13 ]


Tao Liu, Zhiyong Weng, Xiaowu Dong and Yongzhou Hu   Pages 1277 - 1292 ( 16 )


CCR5 (C-C chemokine receptor type 5) is a chemokine receptor that has been identified as a major HIV coreceptor in viral entry and therefore is a highly validated target for the development of new anti-HIV drugs. Here, we discuss the insights gained so far relevant to the development of small-molecule CCR5 inhibitors for the treatment of HIV, and highlight small-molecule CCR5 inhibitors that are currently under preclinical and clinical trials.


HIV, Entry, Co-receptor, CCR5, Small-molecule inhibitor, Maraviroc


ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

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