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DNA Methylation Biomarkers in Serum for Gastric Cancer Screening

[ Vol. 10 , Issue. 11 ]

Author(s):

Ting Ye, Yingxuan Chen and Jingyuan Fang   Pages 1034 - 1038 ( 5 )

Abstract:


Epigenetic alterations occur throughout the development and carcinogenesis of gastric cancer. Therefore, the detection of methylated DNA markers is predicted to be able to detect gastric cancer earlier, and improve the risk assessment, surveillance, relapse, and prognosis of patients with gastric cancer. Detection of free methylated DNA also represents a promising approach for developing serum-based detection methods for the non-invasive monitoring of gastric cancer progression.

Keywords:

DNA methylation, biomarker, serum, gastric cancer, proto-oncogene, tumor suppressor gene, Relapse, Serum-based detection, Non-invasive monitoring, Transcriptional regulation, Proto-oncogenes, Cell cycle regulator genes, Gastric carcinogenesis, Neuroblastoma, Colorectal cancers, Epigenetic alterations, DAP-kinase, Survival prediction

Affiliation:

Department of Gastroenterology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200001, P.R., China.



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