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Cyclodextrins: More than Pharmaceutical Excipients

[ Vol. 10 , Issue. 8 ]

Author(s):

F.J. Otero-Espinar, A. Luzardo-Alvarez and J. Blanco-Mendez   Pages 715 - 725 ( 11 )

Abstract:


Cyclodextrins are pharmaceutical excipients used to enhance the solubility, stability, safety and bioavailability of drugs. Recent findings have shown them to display adjuvant activity in vaccine therapy and prophylactic and therapeutic activity in the treatment of several host-pathogen infections. This article focuses on their activity and mechanism of action.

Keywords:

Cyclodextrins, protein refolding, Bacillus anthracis, Cryptosporidium spp., Human Immunodeficiency Virus, immunomodulation, Leishmania spp., Plasmodium spp.

Affiliation:

Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Campus Universitario sur s/n. 15782 Santiago de Compostela, Spain.



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