Teresa Gonzalez, Miren David, Cristina Moreno, Alvaro Macias and Carmen Valenzuela Pages 635 - 642 ( 8 )
Kv1.5 channels are homotetramers of α-pore subunits mainly present in human atrium and pulmonary vasculature. Thus, Kv1.5 is a pharmacological target for cardiovascular diseases. Kvβ1.3 assemblies with Kvα1.5 and modifies its gating and pharmacology. A further knowledge of α-β interactions and pharmacology will lead a better design of new drugs.
Ion channels, Kv channels, Beta subunits, Kvβ1.3, Kv1.5, Bupivacaine
Instituto de Investigaciones Biomedicas “Alberto Sols” CSIC/UAM, C/ Arturo Duperier 4, 28029 Madrid, Spain.