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Kv1.5-Kvβ Interactions: Molecular Determinants and Pharmacological Consequences

[ Vol. 10 , Issue. 7 ]

Author(s):

Teresa Gonzalez, Miren David, Cristina Moreno, Alvaro Macias and Carmen Valenzuela   Pages 635 - 642 ( 8 )

Abstract:


Kv1.5 channels are homotetramers of α-pore subunits mainly present in human atrium and pulmonary vasculature. Thus, Kv1.5 is a pharmacological target for cardiovascular diseases. Kvβ1.3 assemblies with Kvα1.5 and modifies its gating and pharmacology. A further knowledge of α-β interactions and pharmacology will lead a better design of new drugs.

Keywords:

Ion channels, Kv channels, Beta subunits, Kvβ1.3, Kv1.5, Bupivacaine

Affiliation:

Instituto de Investigaciones Biomedicas “Alberto Sols” CSIC/UAM, C/ Arturo Duperier 4, 28029 Madrid, Spain.



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