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Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents

[ Vol. 9 , Issue. 14 ]

Author(s):

Guizhi Xiao, Hao Fang, Chengguo Xing and Wenfang Xu   Pages 1596 - 1604 ( 9 )

Abstract:


Proteins of Bcl-2(B-cell lymphoma-2) family are key regulators of programmed cell death. Scientist found that some members of this family are over-expressed in malignant tumors and influence the sensitivity of tumor cells to chemotherapy and radiotherapy. This report reviews the recent progress of structures, functions and inhibition of Bcl-2 family proteins, especially the development of Bcl-2 inhibitors in past decades as anticancer agents.

Keywords:

Apoptosis, Bcl-2, structure, function, inhibitors, anti-tumor

Affiliation:

Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong, University, Jinan 250012, P.R. China.



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