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Non-Invasive Approaches to Visualize the Endothelin Axis In Vivo Using State-of-the-Art Molecular Imaging Modalities

[ Vol. 9 , Issue. 14 ]

Author(s):

C. Holtke, A. Faust, H-J. Breyholz, K. Kopka, O. Schober, B. Riemann, C. Bremer, M. Schafers and S. Wagner   Pages 1580 - 1595 ( 16 )

Abstract:


The endothelin (ET) axis plays a major role in cardiovascular diseases and a number of human cancers. This review summarizes the work that has been published in the past ten years using labeled endothelin receptor ligands for the visualization of endothelin receptor expression in vivo.

Keywords:

Molecular imaging, endothelin axis, tumor angiogenesis, endothelial dysfunction, cardiovascular diseases

Affiliation:

Department of Nuclear Medicine, Albert-Schweitzer-Str. 33, University Hospital Munster, 48149 Munster, Germany.



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