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Treating Age-Related Macular Degeneration – Interaction of VEGF-Antagonists with their Target

[ Vol. 9 , Issue. 9 ]

Author(s):

A. Klettner and J. Roider   Pages 1127 - 1135 ( 9 )

Abstract:


The neutralization of VEGF is the current treatment of choice for age-related macular degeneration. Current approaches include anti-VEGF-antibodies and – Fab Fragments, aptamers, soluble receptors (Traps) and siRNA. The molecular properties of VEGF and its antagonists are reviewed and the pathways of action of these substances are discussed.

Keywords:

VEGF, ranibizumab, lucentis, AMD, pegaptanib, VEGF-trap

Affiliation:

UK S-H, Department of Ophthalmology, Campus Kiel, Hegewischstr. 2, 24105 Kiel, Germany.



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