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ABC Transporters as Potential Targets for Modulation of Drug Resistance

[ Vol. 9 , Issue. 9 ]

Author(s):

L. Gatti, G. L. Beretta, G. Cossa, F. Zunino and P. Perego   Pages 1102 - 1112 ( 11 )

Abstract:


ATP binding cassette transporters are implicated in multidrug resistant phenotypes of tumor cells and may be cancer stem cell markers. Inhibitors of drug efflux pumps represent an emerging group of potentially useful agents for the improvement of antitumor therapy. Here we provide an overview of drug transporter functions and modulation.

Keywords:

ATP binding cassette transporters, antitumor drugs, modulators

Affiliation:

Fondazione IRCCS Istituto Nazionale Tumori, via Venezian 1, 20133 Milan, Italy.



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