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Structural Basis for the Design of PPAR-γ Ligands: A Survey on Quantitative Structure- Activity Relationships

[ Vol. 9 , Issue. 9 ]

Author(s):

Costas Giaginis, Stamatios Theocharis and Anna Tsantili-Kakoulidou   Pages 1075 - 1083 ( 9 )

Abstract:


The present review after providing a short overview on PPARs and their pleiotropic action focuses on the QSAR studies reported mainly for PPAR-γ agonists. The different 3D and 2D QSAR models are discussed, their impact in better understanding of the mechanism of action is analyzed and their contribution in the design of new molecules is outlined.

Keywords:

PPAR-γ, type II Diabetes, mechanism of action, 3D-QSAR, 2D-QSAR, drug design

Affiliation:

Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, Athens 157 71, Greece.



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