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The Use of Intravenous Aminobisphosphonates for the Treatment of Pagets Disease of Bone

[ Vol. 9 , Issue. 9 ]

Author(s):

Luigi Gennari, Daniela Merlotti, Giuseppe Mossetti, Domenico Rendina, Vincenzo De Paola, Giuseppe Martini and Ranuccio Nuti   Pages 1052 - 1063 ( 12 )

Abstract:


Pagets disease of bone is a focal skeletal disorder characterized by the formation of structurally abnormal bone, deformity and other complications leading to significant disability and bone pain. Recently, the availability of newer, more potent nitrogen-containing bisphosphonates has improved treatment outcomes, allowing a more effective and convenient management of this disorder.

Keywords:

Paget's disease of bone, bone turnover, bisphosphonates, zoledronic acid, pamidronate, neridronate

Affiliation:

Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Viale Bracci 1, 53100 Siena, Italy.



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