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Antiglucocorticoids, Neurogenesis and Depression

[ Vol. 9 , Issue. 2 ]

Author(s):

Carlos P. Fitzsimons, Lenneke W.A. van Hooijdonk, John A. Morrow, Bernard W.M.M. Peeters, Niall Hamilton, Mark Craighead and Erno Vreugdenhil   Pages 249 - 264 ( 16 )

Abstract:


Recent evidence suggests that antiglucocorticoids, like conventional antidepressants, may recover depressive symptoms by boosting hippocampal neurogenesis. Here, we explore several possible antiglucocorticoid-based antidepressive therapeutic strategies. Firstly, we review specific glucocorticoid receptor/antagonist interactions. Secondly, we discuss a potential new therapeutic target, doublecortin-like kinase, which regulates glucocorticoid signaling in neuronal progenitor cells.

Keywords:

Stress, glucocorticoid receptor, dentate gyrus, hippocampus, neurogenesis, antidepressants, depression, doublecortin- like kinase, anti-glucocorticoids

Affiliation:

LACDR/Medical Pharmacology Department, Leiden University, Gorlaeus Laboratory, Einsteinweg 55, 2333CC Leiden, The Netherlands.



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