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Molecular Modeling Studies of ABC Transporters Involved in Multidrug Resistance

[ Vol. 9 , Issue. 2 ]


Aina Westrheim Ravna and Georg Sager   Pages 186 - 193 ( 8 )


Multidrug resistance (MDR) is a limitation to cancer chemotherapy, antibiotic treatment and HIV medication. Molecular models of the ABC transporters ABCB1 (P-glycoprotein), ABCC4 (multidrug resistance protein 4 (MRP4)) and ABCC5 (MRP5), which are involved in MDR, may aid in the development of drugs inhibiting anticancer agents efflux.


Molecular modeling, P-glycoprotein/ABCB1, MRP4/ABCC4, MRP5/ABCC5, multidrug resistance


Department of Pharmacology, Institute of Medical Biology, University of Tromso, N-9037 Tromso, Norway.

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