Simone Mocellin, Sandro Pasquali and Pierluigi Pilati Pages 70 - 80 ( 11 )
Deregulation of microRNA (miRNA) promotes carcinogenesis, as these molecules can act as oncogenes or tumor suppressor genes. Here we provide an overview of miRNA biology, discuss the most recent findings on miRNA and cancer development/progression, and report on how tumor-related miRNAs (oncomirs) are being used to develop novel cancer specific therapeutic approaches.
MicroRNA, miRNA, oncomirs, cancer biology, molecular targets, anticancer therapeutics
Dept. Oncological&Surgical Sciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy.