Yu Mingyan, Liu Xinyong and Erik De Clercq Pages 60 - 69 ( 10 )
NF-kappaB (NF-κB), the transcription factors of HIV-1, play an important role in triggering HIV transcription. The inhibition of NF-κB activation and their signaling pathway offers a potential anti-HIV therapy strategy. This review reports the mode of action of NF-κB in triggering HIV-1 transcription and the status of the inhibitors.
AIDS, HIV-1, NF-κB, transcription, inhibitor, LTR, IκB, IKK
Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012 P.R. China.