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NF-κB: The Inducible Factors of HIV-1 Transcription and their Inhibitors

[ Vol. 9 , Issue. 1 ]

Author(s):

Yu Mingyan, Liu Xinyong and Erik De Clercq   Pages 60 - 69 ( 10 )

Abstract:


NF-kappaB (NF-κB), the transcription factors of HIV-1, play an important role in triggering HIV transcription. The inhibition of NF-κB activation and their signaling pathway offers a potential anti-HIV therapy strategy. This review reports the mode of action of NF-κB in triggering HIV-1 transcription and the status of the inhibitors.

Keywords:

AIDS, HIV-1, NF-κB, transcription, inhibitor, LTR, IκB, IKK

Affiliation:

Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012 P.R. China.



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