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The Exploding Field of the HCV Polymerase Non-Nucleoside Inhibitors: Summary of a First Generation Compounds

[ Vol. 8 , Issue. 12 ]


Enzo Tramontano   Pages 1298 - 1310 ( 13 )


The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) is strictly essential for viral replication and it has been used as viral target for anti-HCV drug development. All small molecules which have been identified to be selective non-nucleoside inhibitors (NNI) of the HCV RdRp to date are reported.


HCV, RNA dependent RNA polymerase (RdRp), non-nucleoside, inhibition, drug development, antiviral, NNI, small molecules


Department of Sciences and Biomedical Technologies, University of Cagliari, Cittadella di Monserrato, 09142 Monserrato (Cagliari), Italy.

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