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Article Details


Synthesis of Marine Natural Products with Antimalarial Activity

[ Vol. 8 , Issue. 12 ]

Author(s):

Ines Mancini, Graziano Guella and Andrea Defant   Pages 1265 - 1284 ( 20 )

Abstract:


The role played by synthetic organic chemistry of marine metabolites as potential leads for drug discovery of antimalarial agents is discussed. Syntheses of the most promising molecules are summarized, with emphasis on structureactivity relationship (SAR) studies and their mechanism of action.

Keywords:

Natural products, marine metabolites, drug discovery, synthesis, retrosynthetic analysis, antiprotozoal, antimalarial, antiplasmodial

Affiliation:

University of Trento, Centre for Integrative Biology (CIBio), Laboratory of Bioorganic Chemistry, Dept. of Physics, Via Sommarive, 14 I-38050 Povo Trento, Italy.



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