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Caldesmon as a Therapeutic Target for Proliferative Vascular Diseases

[ Vol. 8 , Issue. 12 ]

Author(s):

Chi-Ming Hai   Pages 1209 - 1213 ( 5 )

Abstract:


Caldesmon is a negative regulator of cell proliferation, migration, and metalloproteinase release. Caldesmon function is regulated by multiple kinases, targeting multiple phosphorylation sites. Recently, overexpression of caldesmon has been shown to inhibit neointimal formation after experimental angioplasty, suggesting that caldesmon may be a potential therapeutic target for proliferative vascular diseases.

Keywords:

Actin, atherosclerosis, caldesmon, calmodulin, restenosis, vascular smooth muscle

Affiliation:

Department of Molecular Pharmacology, Physiology&Biotechnology, Brown University, Box G-B3, 171 Meeting Street, Providence, Rhode Island 02912, USA.



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