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Design of Selective G-quadruplex Ligands as Potential Anticancer Agents

[ Vol. 8 , Issue. 11 ]


Jia-Heng Tan, Lian-Quan Gu and Jian-Yong Wu   Pages 1163 - 1178 ( 16 )


G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.


G-quadruplex, G-quartet, ligands, substituted derivatives, affinity and selectivity, DNA interactions, telomerase inhibition


Department of Applied Biology and Chemical Technology and State Key Lab of Chinese Medicine and Molecular Pharmacology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

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