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Hyperglycemia-Related Pathophysiologic Mechanisms and Potential Beneficial Actions of Melatonin

[ Vol. 8 , Issue. 11 ]


Ahmet Korkmaz, Turgut Topal, Sukru Oter, Dun-Xian Tan and Russel J. Reiter   Pages 1144 - 1153 ( 10 )


Chronically-elevated blood glucose initiates a harmful series of processes in which toxic reactive species play crucial roles. Oxidative as well as nitro-oxidative stress is harmful for virtually all biomolecules including lipids, proteins and DNA. Such pathophysiologic mechanisms eventually results in cellular dysfunction, apoptosis or necrosis. Melatonin is a multifunctional indolamine which counteracts several pathophysiologic steps and displays significant beneficial effects against hyperglycemia-induced cellular toxicity. These are related to melatonins antioxidative, anti-inflammatory and possibly epigenetic regulatory properties. Current knowledge encourages using this non-toxic indolamine either as a sole treatment or in conjunction with other treatments for inhibition of the biohazards of hyperglycemia.


Hyperglycemia, free radicals, peroxynitrite, DNA damage, melatonin


Gulhane Askeri Tip Akademisi, Fizyoloji Anabilim Dali, 06018 Ankara, Turkey.

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