Submit Manuscript  

Article Details


Hyperglycemia-Related Pathophysiologic Mechanisms and Potential Beneficial Actions of Melatonin

[ Vol. 8 , Issue. 11 ]

Author(s):

Ahmet Korkmaz, Turgut Topal, Sukru Oter, Dun-Xian Tan and Russel J. Reiter   Pages 1144 - 1153 ( 10 )

Abstract:


Chronically-elevated blood glucose initiates a harmful series of processes in which toxic reactive species play crucial roles. Oxidative as well as nitro-oxidative stress is harmful for virtually all biomolecules including lipids, proteins and DNA. Such pathophysiologic mechanisms eventually results in cellular dysfunction, apoptosis or necrosis. Melatonin is a multifunctional indolamine which counteracts several pathophysiologic steps and displays significant beneficial effects against hyperglycemia-induced cellular toxicity. These are related to melatonins antioxidative, anti-inflammatory and possibly epigenetic regulatory properties. Current knowledge encourages using this non-toxic indolamine either as a sole treatment or in conjunction with other treatments for inhibition of the biohazards of hyperglycemia.

Keywords:

Hyperglycemia, free radicals, peroxynitrite, DNA damage, melatonin

Affiliation:

Gulhane Askeri Tip Akademisi, Fizyoloji Anabilim Dali, 06018 Ankara, Turkey.



Read Full-Text article