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Molecular Structural Characteristics of Estrogen Receptor Modulators as Determinants of Estrogen Receptor Selectivity

[ Vol. 8 , Issue. 9 ]

Author(s):

S. Agatonovic-Kustrin and J. V. Turner   Pages 943 - 951 ( 9 )

Abstract:


This review will discuss the structural determinants and requirements necessary for estrogen receptors alpha and beta selectivity and ligand-receptor binding affinity. In addition, strategies likely to result in the development of a pharmacophore model that account for the differences in estrogenic effects between different ligands will be discussed.

Keywords:

Computer aided drug design, molecular modeling, structure-activity relationship, hormones, drug design, structure, QSAR, phytoestrogens

Affiliation:

School of Medicine–Rural Clinical Division, The University of Queensland, Locked Bag 9009,Toowoomba QLD 4350, Australia.



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