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Role and Pharmacogenomics of TNF-α in Asthma

[ Vol. 8 , Issue. 9 ]


Dimosthenis Lykouras, Fotis Sampsonas, Alexandros Kaparianos, Kiriakos Karkoulias and Kostas Spiropoulos   Pages 934 - 942 ( 9 )


Asthma is a chronic heterogeneous inflammatory disease of the respiratory system in which numerous cytokines play a significant role. Among them TNF-α (tumour necrosis factor α), a proinflammatory cytokine, has a predominant role in orchestrating airway inflammation and affecting treatment outcome. In this review we attempt to summarize the involvement of TNF-α in the pathogenesis of asthma, illustrate variations of TNF-α gene that potentially influence asthma phenotype and highlight promising therapies by blocking the production of TNF-α or inhibiting its action. A cytokine specific target therapy seems to be very promising since agents that block TNF-α slow disease progression, suppress inflammation and in some cases induce remission of chronic inflammation.


Asthma, TNF, inflammatory disease, chronic inflammation., chronic heterpgeneous disease


Pneumology, University Hospital of Patras, Rio, Patras 26500, Greece.

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