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Role and Pharmacogenomics of TNF-α in Asthma

[ Vol. 8 , Issue. 9 ]

Author(s):

Dimosthenis Lykouras, Fotis Sampsonas, Alexandros Kaparianos, Kiriakos Karkoulias and Kostas Spiropoulos   Pages 934 - 942 ( 9 )

Abstract:


Asthma is a chronic heterogeneous inflammatory disease of the respiratory system in which numerous cytokines play a significant role. Among them TNF-α (tumour necrosis factor α), a proinflammatory cytokine, has a predominant role in orchestrating airway inflammation and affecting treatment outcome. In this review we attempt to summarize the involvement of TNF-α in the pathogenesis of asthma, illustrate variations of TNF-α gene that potentially influence asthma phenotype and highlight promising therapies by blocking the production of TNF-α or inhibiting its action. A cytokine specific target therapy seems to be very promising since agents that block TNF-α slow disease progression, suppress inflammation and in some cases induce remission of chronic inflammation.

Keywords:

Asthma, TNF, inflammatory disease, chronic inflammation., chronic heterpgeneous disease

Affiliation:

Pneumology, University Hospital of Patras, Rio, Patras 26500, Greece.



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