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Azathioprine in Multiple Sclerosis

[ Vol. 8 , Issue. 9 ]


Paolo Invernizz, Maria Donata Benedetti, Sarah Poli and Salvatore Monaco   Pages 919 - 926 ( 8 )


Azathioprine is an immunosuppressive and steroid-sparing purine analogue, used in the treatment of several autoimmune diseases. In multiple sclerosis, available evidence suggests that oral azathioprine reduces relapse rates, provides a slight benefit on disability, and reduces new inflammatory lesions. Here, we focus on molecular mechanisms of Azathioprine and on its usefulness in multiple sclerosis.


Azathioprine, multiple sclerosis, immunosuppression, thiopurine methyltransferase, tolerability, relapses, disability, immunomodulators


Department of Neurological and Visual Sciences, Section of Clinical Neurology, University of Verona, Piazzale L.A. Scuro, 10, 37134 Verona, Italy.

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