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Article Details


Azathioprine in Multiple Sclerosis

[ Vol. 8 , Issue. 9 ]

Author(s):

Paolo Invernizz, Maria Donata Benedetti, Sarah Poli and Salvatore Monaco   Pages 919 - 926 ( 8 )

Abstract:


Azathioprine is an immunosuppressive and steroid-sparing purine analogue, used in the treatment of several autoimmune diseases. In multiple sclerosis, available evidence suggests that oral azathioprine reduces relapse rates, provides a slight benefit on disability, and reduces new inflammatory lesions. Here, we focus on molecular mechanisms of Azathioprine and on its usefulness in multiple sclerosis.

Keywords:

Azathioprine, multiple sclerosis, immunosuppression, thiopurine methyltransferase, tolerability, relapses, disability, immunomodulators

Affiliation:

Department of Neurological and Visual Sciences, Section of Clinical Neurology, University of Verona, Piazzale L.A. Scuro, 10, 37134 Verona, Italy.



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