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Apoptosis in Atherosclerosis: A Mini-Review

[ Vol. 8 , Issue. 9 ]

Author(s):

Maria Karaflou, Irene Lambrinoudaki and George Christodoulakos   Pages 912 - 918 ( 7 )

Abstract:


Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle - and inflammatory cells, such as lymphocytes and macrophages, may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.

Keywords:

Atherosclerosis, apoptosis, pathogenesis

Affiliation:

Lecturer Irene Lambrinoudaki, 27, Themistokleous Street, Dionysos, GR-14578, Athens, Greece.



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