Maria Karaflou, Irene Lambrinoudaki and George Christodoulakos Pages 912 - 918 ( 7 )
Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle - and inflammatory cells, such as lymphocytes and macrophages, may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.
Atherosclerosis, apoptosis, pathogenesis
Lecturer Irene Lambrinoudaki, 27, Themistokleous Street, Dionysos, GR-14578, Athens, Greece.