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Small Molecules Targeting p53 to Improve Antitumor Therapy

[ Vol. 8 , Issue. 9 ]

Author(s):

G. L. Beretta, L. Gatti, V. Benedetti, P. Perego and F. Zunino   Pages 856 - 868 ( 13 )

Abstract:


Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.

Keywords:

p53, nutlins, pifithrins, histone deacetylase inhibitors, ubiquitin ligase inhibitors, apoptosis, cancer cells, drug combination

Affiliation:

Fondazione IRCCS Istituto Nazionale Tumori, ViaVenezian 1, 20133Milan, Italy.



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