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HPLC as a Tool in Medicinal Chemistry for the Monitoring of Tricyclic Antidepressants in Biofluids

[ Vol. 8 , Issue. 3 ]

Author(s):

V. F. Samanidou, M. K. Nika and I. N. Papadoyannis   Pages 256 - 275 ( 20 )

Abstract:


HPLC is discussed as an essential tool in medicinal chemistry for the monitoring of tricyclic antidepressants in biofluids, providing clinicians with efficient fast and reliable methods to define individual optimum therapeutic concentrations in treatment of depressions. Additional information on mechanism of action, structure activity relationship and metabolism is provided.

Keywords:

HPLC, tricyclic antidepressants, monitoring, medicinal chemistry, biological fluids

Affiliation:

Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki,Thessaloniki, 541 24 Greece.



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