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Article Details


Malaria Combination Therapies: Advantages and Shortcomings

[ Vol. 8 , Issue. 3 ]

Author(s):

A. Martinelli, R. Moreira and P. V.L. Cravo   Pages 201 - 212 ( 12 )

Abstract:


Drug combination therapies have been devised to delay the development and spread of resistant malaria parasites. However, poor design often leads to ineffective combinations. Here, the properties of various drug combinations are reviewed in relationship to drug resistance and their pharmacokinetic compatibility.

Keywords:

Malaria, drug resistance, drug combination therapy, artemisinin, quinolines, antifolates

Affiliation:

Instituto de Higiene e Medicina Tropical, Rua da Junqueira 96. 1349-008 Lisbon, Portugal.



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