Submit Manuscript  

Article Details


Importance of Iron and Iron Metabolism in Nonalcoholic Fatty Liver Disease

[ Vol. 8 , Issue. 2 ]

Author(s):

Nahum Mendez-Sanchez, Hector Baptista-Gonzalez, Norberto C. Chavez-Tapia, Daniel Zamora-Valdes and Misael Uribe   Pages 171 - 174 ( 4 )

Abstract:


Iron homeostasis disturbances are associated with liver disease. Non-alcoholic steatohepatitis is part of the spectrum of non-alcoholic fatty liver disease, which can progress to hepatic cirrhosis and end-stage liver disease. Increasing information supports that multiple factors underlie the development and progression of nonalcoholic steatohepatitis. However, the relation between non-alcoholic steatohepatitis and iron metabolism/ overload is still controversial. We review the recent literature, both basic and clinical, regarding iron homeostasis as it pertains to the pathogenesis of nonalcoholic fatty liver disease.

Keywords:

Iron, iron overload, insulin resistance, metabolic syndrome, nonalcoholic fatty liver disease

Affiliation:

Departments of Biomedical Research, Gastroenterology&Liver Unit, Medica Sur Clinic&Foundation, Puente de Piedra 150, Col. Toriello Guerra, Mexico City, Mexico.



Read Full-Text article