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Importance of Iron and Iron Metabolism in Nonalcoholic Fatty Liver Disease

[ Vol. 8 , Issue. 2 ]


Nahum Mendez-Sanchez, Hector Baptista-Gonzalez, Norberto C. Chavez-Tapia, Daniel Zamora-Valdes and Misael Uribe   Pages 171 - 174 ( 4 )


Iron homeostasis disturbances are associated with liver disease. Non-alcoholic steatohepatitis is part of the spectrum of non-alcoholic fatty liver disease, which can progress to hepatic cirrhosis and end-stage liver disease. Increasing information supports that multiple factors underlie the development and progression of nonalcoholic steatohepatitis. However, the relation between non-alcoholic steatohepatitis and iron metabolism/ overload is still controversial. We review the recent literature, both basic and clinical, regarding iron homeostasis as it pertains to the pathogenesis of nonalcoholic fatty liver disease.


Iron, iron overload, insulin resistance, metabolic syndrome, nonalcoholic fatty liver disease


Departments of Biomedical Research, Gastroenterology&Liver Unit, Medica Sur Clinic&Foundation, Puente de Piedra 150, Col. Toriello Guerra, Mexico City, Mexico.

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