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Interactions of Polyphenols with the P450 System: Possible Implications on Human Therapeutics

[ Vol. 8 , Issue. 2 ]


M. J. Gomez-Lechon, I. Rodeiro, M. T. Donato, A. Lahoz, G. Garrido and R. Delgado   Pages 97 - 106 ( 10 )


Polyphenols are a family of natural compounds with many biological properties. This review focuses on their potential interaction on the cytochrome P450 system. Effects of phenolic acids, anthocyanins, stilbenes, catechins and other flavonoids on the drug metabolising function are revised. Their daily intake and presence in herbal medicines justify the study of potential drug-interaction to prevent undesirable clinical consequences.


Antioxidants, flavonoids, polyphenols, cytochrome P450, herbal medicines


Unidad de Hepatologia Experimental,Centro de Investigacion, Hospital La Fe, Avda Campanar 21,46009-Valencia, Spain.

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