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Targeting the Viral Nucleocapsid Protein in Anti-HIV-1 Therapy

[ Vol. 8 , Issue. 1 ]

Author(s):

Yves Mely, Hugues de Rocquigny, Volodymyr Shvadchak, Sergiy Avilov, Chang Zhi Dong, Ursula Dietrich and Jean-Luc Darlix   Pages 24 - 35 ( 12 )

Abstract:


The nucleocapsid protein (NC) plays seminal roles in HIV replication, thus representing a major drug target. NC functions rely on its two zinc-fingers and flanking basic residues. Zinc ejectors inhibit NC functions, but with limited specificity. New classes of molecules competing with NC or its viral nucleic acid and enzyme partners are reviewed here.

Keywords:

NCp7, zinc ejector, library, HIV, structure, peptidomimetic, aptamer, intercalator

Affiliation:

Institut Gilbert Laustriat, Photophysique des interactions moleculaires, UMR 7175 CNRS, Faculte de Pharmacie, Universite Louis Pasteur, Strasbourg 1, 74, Route du Rhin, 67401 ILLKIRCH Cedex, France.



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