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Peripheral and Dual Binding Site Acetylcholinesterase Inhibitors: Implications in treatment of Alzheimers Disease

[ Vol. 1 , Issue. 3 ]

Author(s):

Ana Castro and Ana Martinez   Pages 267 - 272 ( 6 )

Abstract:


Recently advances in understanding the molecular basis of Alzheimers disease have led to the consideration of the relationship between cholinergic inhibitors and amyloid deposition as a new hypothesis for the future rational design of effective anti-Alzheimer drugs. In the present review, the non-cholinergic functions of acetylcholinesterase (AChE) and the therapeutic potential of peripheral and dual binding site AChE inhibitors in delaying the neurodegenerative process will be discussed.

Keywords:

Acetylcholinesterase Inhibitors, Alzheimers Disease, Anti-Alzheimer drugs

Affiliation:

Instituto de Quimica Medica (C.S.I.C.), Juan de la Cierva, 3, 28006 Madrid (Spain)



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