Ana Castro and Ana Martinez Pages 267 - 272 ( 6 )
Recently advances in understanding the molecular basis of Alzheimers disease have led to the consideration of the relationship between cholinergic inhibitors and amyloid deposition as a new hypothesis for the future rational design of effective anti-Alzheimer drugs. In the present review, the non-cholinergic functions of acetylcholinesterase (AChE) and the therapeutic potential of peripheral and dual binding site AChE inhibitors in delaying the neurodegenerative process will be discussed.
Acetylcholinesterase Inhibitors, Alzheimers Disease, Anti-Alzheimer drugs
Instituto de Quimica Medica (C.S.I.C.), Juan de la Cierva, 3, 28006 Madrid (Spain)