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Daphnane-Type Diterpene Orthoesters and their Biological Activities

[ Vol. 2 , Issue. 2 ]

Author(s):

Weidong He, Miroslav Cik, Giovanni Appendino, Luc Van Puyvelde, Josee E. Leysen and Norbert De Kimpe   Pages 185 - 200 ( 16 )

Abstract:


Daphnane orthoesters are the active ingredients of plant remedies from the Western, Chinese and African traditional medicine, and have provided important tools to investigate medicinally relevant processes like tumour promotion, apoptosis, neurotrophism, and VR1 activation. The occurrence, biological activity, and molecular pharmacology of these compounds will be reviewed.

Keywords:

Daphnane-Type, Diterpene Orthoesters

Affiliation:

Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, GhentUniversity, Coupure Links 653, B-9000 Ghent, Belgium



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