Medicinal Chemistry of Nicotinamide in the Treatment of Ischemia and Reperfusion

Author(s):

J. Yang, L. K. Klaidman and J. D. Adams   Pages 125 - 134 ( 10 )

Abstract:

Nicotinamide can facilitate DNA repair by inhibiting poly(ADP-ribose) polymerase, increasing NAD levels and adjusting other related enzyme activities. This review will summarize recent work on the design of poly(ADP-ribose) polymerase inhibitors, poly(ADP-ribose) glycohydrolase inhibitors and will discuss the possible use of drugs that interact with NAD synthetic enzymes.

Keywords:

nicotinamide, poly(adp-ribose) polymerase inhibitors, poly(adp-ribose)glycohydrolase inhibitors, glycohydrolase

Affiliation:

School of Pharmacy,University of Southern California, 1985 Zonal Avenue, Los Angeles,California 90089, USA

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