J. Yang, L. K. Klaidman and J. D. Adams Pages 125 - 134 ( 10 )
Nicotinamide can facilitate DNA repair by inhibiting poly(ADP-ribose) polymerase, increasing NAD levels and adjusting other related enzyme activities. This review will summarize recent work on the design of poly(ADP-ribose) polymerase inhibitors, poly(ADP-ribose) glycohydrolase inhibitors and will discuss the possible use of drugs that interact with NAD synthetic enzymes.
nicotinamide, poly(adp-ribose) polymerase inhibitors, poly(adp-ribose)glycohydrolase inhibitors, glycohydrolase
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