Molecular Pharmacophore Determination of Lipid Lowering Drugs with the Receptor Mapping Method

Author(s):

M. Ablise, A. Cartier, G. Siest, S. Visvikis and V. Loppinet   Pages 97 - 102 ( 6 )

Abstract:

Hypolipidemic pharmacophoric moieties of statins, fibrates, ACAT inhibitors and beta-sitosterol analog series were identified by computational modeling, and compared with the computed structure of new potential glycyrrhetinic acid derivatives lipid-lowering drugs. Their electronic and geometric domains, similar to those of fibrates, suggest a fibrate -like mechanism matching biochemical data.

Keywords:

acat inhibitors, molecular modeling, glycyrrhizin, glycyrrhiza glabra

Affiliation:

Xinjiang Medical University(XMU), College of Pharmacy, 8, Xin Yi Road, 830054-URUMQI, P R ofChina

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