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Recent Advances in Topoisomerase I-Targeting Agents, Camptothecin Analogues

[ Vol. 2 , Issue. 6 ]

Author(s):

Dae-Kee Kim and Namkyu Lee   Pages 611 - 619 ( 9 )

Abstract:


The present review concentrates on camptothecin (CPT) analogues, the most extensively studied topoisomerase I (topo I) inhibitors, and provides concise information on the structural features of human topo I enzyme, mechanisms of interaction of CPT with topo I, structure-activity relationship study of CPT analogues including the influence of lactone stability on antitumor activity, and recent updates of valuable CPT analogues.

Keywords:

topoisomerase, camptothecin, structural features of human topo enzyme, structure-activity relationship, monomeric protein, lurtotecan, rubitecan, highly lipophilic

Affiliation:

Life Science Research Center, SK Chemicals, 600 Jungja-Dong, Changan-Ku, Suwon-Si, Kyungki-Do 440-745, Korea



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