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Recent Advances in Topoisomerase I-Targeting Agents, Camptothecin Analogues

[ Vol. 2 , Issue. 6 ]


Dae-Kee Kim and Namkyu Lee   Pages 611 - 619 ( 9 )


The present review concentrates on camptothecin (CPT) analogues, the most extensively studied topoisomerase I (topo I) inhibitors, and provides concise information on the structural features of human topo I enzyme, mechanisms of interaction of CPT with topo I, structure-activity relationship study of CPT analogues including the influence of lactone stability on antitumor activity, and recent updates of valuable CPT analogues.


topoisomerase, camptothecin, structural features of human topo enzyme, structure-activity relationship, monomeric protein, lurtotecan, rubitecan, highly lipophilic


Life Science Research Center, SK Chemicals, 600 Jungja-Dong, Changan-Ku, Suwon-Si, Kyungki-Do 440-745, Korea

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