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Malaria: New Chemotherapeutic Peroxide Drugs

[ Vol. 2 , Issue. 6 ]

Author(s):

Kristina Borstnik, Ik-hyeon Paik and Gary H. Posner   Pages 573 - 583 ( 11 )

Abstract:


Chemical insights into artemisinins biological mechanism of action have allowed rational design of some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarizes recent achievements in this area of peroxide drug development for malaria chemotherapy.

Keywords:

malaria, chemotherapeutic peroxide drugs, artemisinin biological mechanism, malaria chemotherapy, antimalarial peroxide artemisinin, anopheline mosquitoes, host bloodstream, aggregation, acute encephalopathy

Affiliation:

Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA



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