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Structure-activity Relationship, Conformation and Pharmacology Studies of Morphiceptin Analogues - Selective μ-Opioid Receptor Ligands

[ Vol. 2 , Issue. 6 ]


Anna Janecka, Jakub Fichna, Marek Mirowski and Tomasz Janecki   Pages 565 - 572 ( 8 )


Morphiceptin (Tyr-Pro-Phe-Pro-NH2) is one of the most selective agonists for the μ-opioid receptor. In this review structure-activity relationships of morphiceptin analogues and studies resulting in defining low energy conformations are discussed. Finally, new developments in the control of tumour growth and cell proliferation by morphiceptin analogues are surveyed, which open future perspectives in the diagnosis and treatment of various cancers.


morphiceptin analogues, opioid receptor ligands, diagnosis, enkephalins, opiate-like properties, receptor ligands, physiological activity, opioid activity, cyclic analogues, potential pharmaceutical agents


Department of Medicinal Chemistry, Medical University of Lodz, Lindleya 6, 90-131 Lodz, Poland

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