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Polyamine Metabolism as Chemotherapeutic Target in Protozoan Parasites

[ Vol. 2 , Issue. 6 ]

Author(s):

C. J. Bacchi and N. Yarlett   Pages 553 - 563 ( 11 )

Abstract:


Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono- and di-substituted polyamine analogs targeting polyamine interconversion, as well as more traditional targeting of synthetic enzymes and related pathways.

Keywords:

chemotherapeutic target, protozoan parasites, polyamine analogs, ornithine decarboxylase, backconversion pathway, african trypanosomes, nucleoside transporters, dfmo

Affiliation:

Haskins Laboratories and Departments of Biology, Pace University, 41 Park Row, New York, NY 10038, USA



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