H. Sakurai, J. Fugono and H. Yasui Pages 41 - 48 ( 8 )
To treat patients suffering from diabetes mellitus, we developed several types of orally active vanadyl complexes to replace painful insulin injections, and prepared them in the form of enteric-coated capsules containing vanadium compounds. Pharmacokinetic analysis demonstrated that these capsules enhance the bioavailability of pharmacologically active vanadyl species.
Vanadyl compound, insulinomimetic activity, diabetes mellitus, blood circulation monitoring-electron, paramagnetic resonance (BCM-EPR), pharmacokinetic analysis, bioavailability, enteric-coated capsule
Department of Analyticaland Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan