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Pharmacokinetic Study and Trial for Preparation of Enteric-Coated Capsule Containing Insulinomimetic Vanadyl Compounds: Implications for Clinical Use

[ Vol. 4 , Issue. 1 ]

Author(s):

H. Sakurai, J. Fugono and H. Yasui   Pages 41 - 48 ( 8 )

Abstract:


To treat patients suffering from diabetes mellitus, we developed several types of orally active vanadyl complexes to replace painful insulin injections, and prepared them in the form of enteric-coated capsules containing vanadium compounds. Pharmacokinetic analysis demonstrated that these capsules enhance the bioavailability of pharmacologically active vanadyl species.

Keywords:

Vanadyl compound, insulinomimetic activity, diabetes mellitus, blood circulation monitoring-electron, paramagnetic resonance (BCM-EPR), pharmacokinetic analysis, bioavailability, enteric-coated capsule

Affiliation:

Department of Analyticaland Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan



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