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The Wide Pharmacological Versatility of Semicarbazones, Thiosemicarbazones and Their Metal Complexes

[ Vol. 4 , Issue. 1 ]

Author(s):

H. Beraldo and D. Gambinob   Pages 31 - 39 ( 9 )

Abstract:


The more significant bioactivities of a variety of semicarbazones (anti-protozoa, anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and their metal complexes are reviewed together with proposed mechanisms of action and structure-activity relationships. Clinical or potential pharmacological applications of these versatile compounds are discussed.

Keywords:

Semicarbazones, thiosemicarbazones, biological activity, pharmacological applications, bioactive metal complexes, mechanisms of action

Affiliation:

Departamento de Quimica,Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG,Brazil



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