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The Wide Pharmacological Versatility of Semicarbazones, Thiosemicarbazones and Their Metal Complexes

[ Vol. 4 , Issue. 1 ]


H. Beraldo and D. Gambinob   Pages 31 - 39 ( 9 )


The more significant bioactivities of a variety of semicarbazones (anti-protozoa, anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and their metal complexes are reviewed together with proposed mechanisms of action and structure-activity relationships. Clinical or potential pharmacological applications of these versatile compounds are discussed.


Semicarbazones, thiosemicarbazones, biological activity, pharmacological applications, bioactive metal complexes, mechanisms of action


Departamento de Quimica,Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG,Brazil

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