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Predicting Synthetic Accessibility: Application in Drug Discovery and Development

[ Vol. 4 , Issue. 6 ]

Author(s):

J. C. Baber and M. Feher   Pages 681 - 692 ( 12 )

Abstract:


The estimation and use of synthetic accessibility in the drug discovery process is discussed. A distinction is drawn between synthetic feasibility and accessibility and the practical uses of an accessibility score are examined. Various techniques used in the estimation of accessibility are described and their utility and potential accuracy compared.

Keywords:

synthetic accessibility, synthetic feasibility, drug discovery, drug development, screening, prioritization, retrosynthetic analysis

Affiliation:

Neurocrine BiosciencesInc., 10555 Science Center Drive, San Diego, California 92121, USA



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