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New Developments on Thromboxane Modulators

[ Vol. 4 , Issue. 6 ]

Author(s):

Jean-Michel Dogne, Julien Hanson, Xavier de Leval, Bernard Masereel, Philippe Kolh and Bernard Pirotte   Pages 649 - 657 ( 9 )

Abstract:


Thromboxane A2 (TXA2) is a labile product formed from arachidonic acid by cyclooxygenase. The pathogenesis of numerous cardiovascular, pulmonary, and thromboembolic diseases can be related to this metabolite. Therefore, TXA2 modulators have been developed for 20 years. This review will highlight the evolution in the field of TXA2 modulators.

Keywords:

thromboxane a2, arachidonic acid, thromboxane synthase, prostanoids

Affiliation:

Natural and Synthetic DrugResearch Centre, Medicinal Chemistry, University of Liège, 1, av. del'Hôpital, B-4000 Liège, Belgium



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