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Structural Approach for COX-2 Inhibition

[ Vol. 4 , Issue. 6 ]

Author(s):

C. Michaux and C. Charlier   Pages 603 - 615 ( 13 )

Abstract:


The design of selective COX-2 inhibitors is a new approach to obtain potent, anti-inflammatory drugs but with less side effects. Several families of such inhibitors were reported in literature. In this review, the drug design processes used to understand their binding mode and the origin of selectivity of these compounds are described.

Keywords:

cox-2 inhibitor, selectivity, molecular modelling, x-ray, drug design, cox binding site, molecular features

Affiliation:

Laboratory of Molecular and Structural Chemistry, Facultes Universitaires N.-D. de la Paix, 61 ruede Bruxelles, B-5000 Namur, Belgium



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