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First and Second Generations of COX-2 Selective Inhibitors

[ Vol. 4 , Issue. 6 ]


Xavier de Leval, Fabien Julemont, Valerie Benoit, Michel Frederich, Bernard Pirotte and Jean-Michel Dogne   Pages 597 - 601 ( 5 )


The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.


cox-2 inhibitors, cox-2 selectivity, pre-clinical data


University of Liege, Natural and Synthetic Drugs, Research Center, Department of MedicinalChemistry, 1, avenue de l'Hopital, tour 4(+5), B-4000 Liege (Belgium)

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