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Development of Radioligands for In Vivo Imaging of GABAA-Benzodiazepine Receptors

[ Vol. 4 , Issue. 8 ]

Author(s):

Andrew Katsifis and Michael Kassiou   Pages 909 - 921 ( 13 )

Abstract:


Changes in the biochemical integrity and function of the GABAA-benzodiazepine receptor (BZR) complex have been implicated in various neurological and psychiatric disorders. The development of specific radioligands for the GABAA-BZR have not only contributed to the elucidation of the receptors biochemical functions, but also provided a means by which these changes are correlated to disease states when studied with the functional imaging modalities of positron emission tomography (PET) and single photon emission computed tomography (SPECT).

Keywords:

benzodiazepines, cns receptors, radioligands, pet, spect

Affiliation:

Radiopharmaceuticals Division R&D, Australian Nuclear Science and Technology OrganisationPrivate Mail Bag 1, Menai NSW 2234, Sydney, Australia.



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