Andrew Katsifis and Michael Kassiou Pages 909 - 921 ( 13 )
Changes in the biochemical integrity and function of the GABAA-benzodiazepine receptor (BZR) complex have been implicated in various neurological and psychiatric disorders. The development of specific radioligands for the GABAA-BZR have not only contributed to the elucidation of the receptors biochemical functions, but also provided a means by which these changes are correlated to disease states when studied with the functional imaging modalities of positron emission tomography (PET) and single photon emission computed tomography (SPECT).
benzodiazepines, cns receptors, radioligands, pet, spect
Radiopharmaceuticals Division R&D, Australian Nuclear Science and Technology OrganisationPrivate Mail Bag 1, Menai NSW 2234, Sydney, Australia.