Submit Manuscript  

Article Details


Intervention of Hepatic Glucose Production. Small Molecule Regulators of Potential Targets for Type 2 Diabetes Therapy

[ Vol. 4 , Issue. 8 ]

Author(s):

Tjeerd Barf   Pages 897 - 908 ( 12 )

Abstract:


Excessive hepatic glucose production is thought to be a major contributor to the type 2 diabetic state. Drug discovery efforts have yielded small synthetic inhibitors for gluconeogenic and glycogenic regulators of this pathway. The most advanced targets are outlined in this mini-review and include: the glucocorticoid receptor, 11β-hydroxysteroid dehydrogenase type 1, fructose 1,6-bisphosphatase, the glucagon receptor, glycogen phosphorylase, glycogen synthase kinase-3, and glucose-6-phosphatase.

Keywords:

glucocorticoid receptor, f16bpase, glycogen phosphorylase, glucagon receptor, gsk-3, g6pase

Affiliation:

Department of Medicinal Chemistry, Biovitrum AB, Box 6443, SE-751 37 Uppsala, Sweden.



Read Full-Text article