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Involvement of PI3K/Akt Pathway in Prostate Cancer - Potential Strategies for Developing Targeted Therapies

[ Vol. 5 , Issue. 12 ]

Author(s):

Nicole Pommery and Jean-Pierre Henichart   Pages 1125 - 1132 ( 8 )

Abstract:


This review presents some therapeutic interventions actually considered in prostate cancer therapy to compensate constitutive activation of the PI3K/Akt signalling pathway induced, particularly, by mutations of PTEN gene. Special emphasis is placed on applicability of EGF-R tyrosine kinase, COX-2, PDK-1, mTOR and farnesyltransferase inhibitors.

Keywords:

Prostate cancer, PI3K/Akt/mTOR pathway, growth inhibition

Affiliation:

Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, Lille, France.



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