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A2B Adenosine Receptor Antagonists: Recent Developments

[ Vol. 5 , Issue. 12 ]

Author(s):

Barbara Cacciari, Giorgia Pastorin, Chiara Bolcato, Giampiero Spalluto, Magdalena Bacilieri and Stefano Moro   Pages 1053 - 1060 ( 8 )

Abstract:


There are pharmacological evidences that A2B receptors are involved in inflammatory processes, such as asthma. For this reason, many efforts has been made for identifying selective A2B antagonists as antiasthmatic agents. The updated material related to this field has been rationalised and arranged in order to offer an overview of the topic.

Keywords:

endogenous nucleoside, adenosine receptors subtypes, protein Kinase C (PKC), Xanthine Derivatives, Triazolo-Triazine Derivatives, GPCRs

Affiliation:

Dipartimento di Scienze Farmaceutiche, Piazzale Europa 1, I-34127 Trieste, Italy.



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